Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 10/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | EED | O75530 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 3/20 | 0.30 |
| ▸ | BCHE | P06276 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5743895 | 0.84 | HTR2C (0.40) | HTR2CHTR2AHTR2BSIGMAR1HTR1A | |
| SCHEMBL7600224 | 0.79 | HTR2C (0.42) | HTR2CHTR2AHTR2BSIGMAR1HTR1A | |
| Ammonia Solution, Strong SCHEMBL14677992 | 0.78 | HTR2C (0.41) | HTR2CHTR2AHTR2BSIGMAR1HTR1A | |
| SCHEMBL30000911 | 0.76 | HTR2C (0.42) | HTR2CHTR2AHTR2BSIGMAR1HTR1A | |
| SCHEMBL4429415 | 0.61 | PAX8 (0.48) | HTR2CHTR2AHTR2BMAOBNFKB1 | |
| SCHEMBL13983903 | 0.60 | HTR2C (0.66) | HTR2CHTR2AHTR2BHTR1ADRD3 | |
| SCHEMBL3633037 | 0.59 | HTR2A (0.46) | HTR2CHTR2AHTR2BHTR1ADRD3 | |
| SCHEMBL1555111 | 0.58 | HTR2A (0.45) | HTR2CHTR2AHTR2BSIGMAR1HTR1A | |
| SCHEMBL9411925 | 0.58 | HTR2C (0.57) | HTR2CHTR2AHTR2BHTR1ADRD3 | |
| SCHEMBL15465932 | 0.57 | PAX8 (0.45) | HTR2CHTR2AHTR2BMAOBNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0586254-A1 | Furanoindoline derivatives and their use as antitumor agents | ELI LILLY AND COMPANY (US) | 1994-03-09 | — | — | EP | disclosed |
| US-5248691-A | Antitumor agent | ELI LILLY AND COMPANY (US) | 1993-09-28 | — | — | US | disclosed |