SCHEMBL9413315

SCHEMBL9413315

Cc1nc(NC2CCCC2)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@@]3(C)O)c2n1

nearest known ligand 0.81

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 11/20 0.81
ADORA3 P0DMS8 10/20 0.81
ADORA2A P29274 7/20 0.81
ADORA2B P29275 6/20 0.81
ALOX15 P16050 1/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12194756 0.91 ADORA1 (0.81) ADORA1ADORA3ADORA2AADORA2BALOX15
SCHEMBL12219205 0.91 ADORA1 (0.81) ADORA1ADORA3ADORA2AADORA2BALOX15
SCHEMBL2509912 0.91 ADORA1 (0.81) ADORA1ADORA3ADORA2AADORA2BALOX15
SCHEMBL1914129 0.90 ADORA1 (1.00) ADORA1ADORA3ADORA2AADORA2BALOX15
SCHEMBL29385091 0.90 ADORA1 (1.00) ADORA1ADORA3ADORA2AADORA2BALOX15
SCHEMBL14829529 0.90 ADORA1 (1.00) ADORA1ADORA3ADORA2AADORA2BALOX15
SCHEMBL2509742 0.90 ADORA1 (0.80) ADORA1ADORA3ADORA2AADORA2BALOX15
SCHEMBL6382804 0.87 ADORA3 (1.00) ADORA1ADORA3ADORA2AADORA2BALOX15
SCHEMBL21136921 0.86 ADORA3 (0.60) ADORA1ADORA3ADORA2AADORA2BALOX15
SCHEMBL21136562 0.86 ADORA1 (0.74) ADORA1ADORA3ADORA2AADORA2BALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0601322-A2 Adenosindeaminase inhibitor NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) 1994-06-15 EP disclosed