Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 8/20 | 0.40 |
| ▸ | TOP2B | Q02880 | 8/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 6/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9416465 | 0.89 | TOP2A (0.42) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL9416480 | 0.86 | TOP2A (0.43) | TOP2ATOP2BPOLBALDH1A1OPRM1 | |
| SCHEMBL9416446 | 0.86 | TOP2A (0.40) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL8785059 | 0.84 | TOP2A (0.39) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL6216986 | 0.83 | MEN1 (0.46) | TOP2ATOP2BPOLBMEN1KMT2A | |
| SCHEMBL9152025 | 0.82 | TOP2A (0.55) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL9047079 | 0.82 | MEN1 (0.39) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL1972628 | 0.81 | ALDH1A1 (0.49) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL10377398 | 0.81 | TOP2A (0.40) | TOP2ATOP2BPOLBALDH1A1CHRM2 | |
| SCHEMBL6217926 | 0.80 | TOP2A (0.45) | TOP2ATOP2BPOLBALDH1A1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0607825-A1 | 6-H-4-OXO-3-quinoline-carboxylic acids and their analogues as antibacterial agents | BAYER AG (DE) | 1994-07-27 | — | — | EP | disclosed |