Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | MGAM | O43451 | 1/20 | 0.45 |
| ▸ | SI | P14410 | 1/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28709820 | 0.84 | KMT2A (0.69) | TSHRMEN1KMT2APKMMAPT | |
| SCHEMBL2711919 | 0.84 | KMT2A (0.49) | MEN1KMT2AALDH1A1 | |
| SCHEMBL680836 | 0.83 | TSHR (0.69) | TSHRMEN1KMT2AHPGDGAA | |
| SCHEMBL28067898 | 0.81 | KDM4E (0.60) | MEN1KMT2AHPGDMAPTHSD17B10 | |
| SCHEMBL8880319 | 0.80 | L3MBTL1 (0.59) | TSHRMEN1KMT2AHPGDPKM | |
| SCHEMBL13019006 | 0.78 | KMT2A (0.56) | TSHRMEN1KMT2AGAAMAPT | |
| SCHEMBL6566870 | 0.78 | HPGD (0.56) | TSHRMEN1KMT2AHPGDPKM | |
| SCHEMBL9830975 | 0.77 | TOP2A (0.47) | GAAMGAMSIMGAM2MAPT | |
| SCHEMBL11437459 | 0.76 | KMT2A (0.64) | TSHRMEN1KMT2AGAAMAPT | |
| SCHEMBL30174284 | 0.76 | TSHR (0.52) | TSHRMEN1KMT2AHPGDPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2445886-B1 | 4-AMINOQUINOLINE DERIVATIVES AS PI3K INHIBITORS | AMGEN INC (US) | 2016-03-30 | — | — | EP | disclosed |
| US-5292937-A | Use of malonic acid derivative compounds for retarding plant growth | RHONE-POULENC INC. (US) | 1994-03-08 | — | — | US | disclosed |
| US-5123951-A | Ethylene response inducing agent and malonic acid derivative | RHONE-POULENC NEDERLAND B.V. (NL) | 1992-06-23 | — | — | US | disclosed |