Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | PI4KA | P42356 | 1/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.39 |
| ▸ | FAP | Q12884 | 3/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | POLA1 | P09884 | 1/20 | 0.36 |
| ▸ | POLG | P54098 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.36 |
| ▸ | AHCY | P23526 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9555763 | 1.00 | ADORA2A (0.39) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9417129 | 0.90 | DAPK1 (0.33) | FBP1FGFR1 | |
| SCHEMBL9555589 | 0.86 | MAPK1 (0.33) | FAP | |
| SCHEMBL9417158 | 0.84 | FAP (0.44) | ADORA2AFAPCYP3A4CYP2D6FGFR1 | |
| SCHEMBL9555527 | 0.84 | FAP (0.44) | ADORA2AFAPCYP3A4CYP2D6FGFR1 | |
| SCHEMBL9555568 | 0.84 | FAP (0.44) | ADORA2AFAPCYP3A4CYP2D6FGFR1 | |
| SCHEMBL9555542 | 0.83 | FAP (0.36) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9555536 | 0.83 | FAP (0.36) | ADORA2API4KAPI4K2BPI4K2API4KB | |
| SCHEMBL9417200 | 0.83 | HPRT1 (0.46) | — | |
| SCHEMBL9417235 | 0.82 | FAP (0.46) | ADORA2AFAPCYP3A4CYP2D6FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319228-B1 | Novel compounds | BEECHAM GROUP PLC (GB) | 1994-11-02 | — | — | EP | disclosed |
| US-5247085-A | Phosphonate containing purine compounds | BEECHAM GROUP P.L.C. (GB) | 1993-09-21 | — | — | US | disclosed |
| EP-0319228-A2 | Novel compounds | BEECHAM GROUP PLC (GB) | 1989-06-07 | — | — | EP | disclosed |