Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.62 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL855216 | 0.97 | — | — | |
| SCHEMBL8554508 | 0.95 | HRH3 (0.70) | HRH3KEAP1SMN1; SMN2SIGMAR1ALOX15 | |
| SCHEMBL6347703 | 0.95 | HRH3 (0.70) | HRH3KEAP1SMN1; SMN2SIGMAR1ALOX15 | |
| SCHEMBL854695 | 0.95 | HRH3 (0.70) | HRH3KEAP1SMN1; SMN2SIGMAR1ALOX15 | |
| SCHEMBL11179088 | 0.95 | HRH3 (0.70) | HRH3KEAP1SMN1; SMN2SIGMAR1ALOX15 | |
| SCHEMBL21799578 | 0.92 | HRH3 (0.75) | HRH3KEAP1SMN1; SMN2SIGMAR1ALOX15 | |
| Hydrazine SCHEMBL8556857 | 0.92 | HRH3 (0.67) | HRH3KEAP1SMN1; SMN2SIGMAR1ALOX15 | |
| SCHEMBL21799504 | 0.92 | HRH3 (0.75) | HRH3KEAP1SMN1; SMN2SIGMAR1ALOX15 | |
| SCHEMBL21799790 | 0.92 | HRH3 (0.75) | HRH3KEAP1SMN1; SMN2SIGMAR1ALOX15 | |
| SCHEMBL7230416 | 0.92 | HRH3 (0.75) | HRH3KEAP1SMN1; SMN2SIGMAR1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373095-A | Steroid compounds | THE UPJOHN COMPANY (US) | 1994-12-13 | — | — | US | disclosed |
| US-5274089-A | A estra-1,3,5(10)-triene derivative | THE UPJOHN COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| US-5196542-A | Phospholipase A2 inhibitors | THE UPJOHN COMPANY (US) | 1993-03-23 | — | — | US | disclosed |
| US-5187299-A | Phospholipase inhibitors; treating diabetes, obesity | THE UPJOHN COMPANY (US) | 1993-02-16 | — | — | US | disclosed |
| US-5145874-A | Phospholipase inhibitor, hypoglycemic agent, antidiabetic, obesity | THE UPJOHN COMPANY (US) | 1992-09-08 | — | — | US | disclosed |