Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417283 | 0.90 | REN (0.71) | REN | |
| SCHEMBL9417321 | 0.89 | REN (0.56) | REN | |
| SCHEMBL10555025 | 0.89 | REN (0.56) | REN | |
| SCHEMBL10794397 | 0.88 | REN (0.67) | REN | |
| SCHEMBL10557173 | 0.87 | REN (0.52) | REN | |
| SCHEMBL9282508 | 0.79 | PSEN1 (0.59) | REN | |
| SCHEMBL7266599 | 0.79 | REN (0.58) | REN | |
| SCHEMBL5709671 | 0.79 | PSEN1 (0.59) | REN | |
| SCHEMBL6696371 | 0.79 | REN (0.58) | REN | |
| SCHEMBL7272241 | 0.79 | REN (0.58) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0229667-B1 | Peptidylaminodiols | ABBOTT LAB (US) | 1994-07-13 | — | — | EP | disclosed |
| US-5214129-A | Amidation of a protected amino acid by an di-O-protected dihydroxy-containing amine and coupling with a carboxylic acid; deprotecting; renin inhibitors; hypotensive agents | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |
| US-5091575-A | Renin inhibitor | ABBOTT LABORATORIES (US) | 1992-02-25 | — | — | US | disclosed |