Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 8/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417879 | 1.00 | LTB4R (0.43) | LTB4RLTB4R2NR1H4MEN1CYP3A4 | |
| SCHEMBL9417782 | 1.00 | LTB4R (0.43) | LTB4RLTB4R2NR1H4MEN1CYP3A4 | |
| SCHEMBL9417929 | 1.00 | LTB4R (0.43) | LTB4RLTB4R2NR1H4MEN1CYP3A4 | |
| SCHEMBL9417852 | 1.00 | LTB4R (0.43) | LTB4RLTB4R2NR1H4MEN1CYP3A4 | |
| SCHEMBL9417877 | 0.99 | LTB4R (0.42) | LTB4RLTB4R2NR1H4MEN1CYP3A4 | |
| SCHEMBL9417953 | 0.96 | LTB4R (0.42) | LTB4RLTB4R2NR1H4MEN1CYP3A4 | |
| SCHEMBL9417866 | 0.89 | LTB4R (0.44) | LTB4RLTB4R2NR1H4MEN1CYP3A4 | |
| SCHEMBL9417971 | 0.88 | LTB4R (0.53) | LTB4RLTB4R2NR1H4MEN1CYP3A4 | |
| SCHEMBL9417928 | 0.87 | NR1H4 (0.44) | NR1H4ALDH1A1MAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL9417975 | 0.87 | LTB4R (0.42) | LTB4RLTB4R2NR1H4MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294613-A | Benzene derivatives of p-substituted ether and acid or ester | ELI LILLY AND COMPANY (US) | 1994-03-15 | — | — | US | disclosed |
| US-4945099-A | LEUKOTRIENE ANTAGONIST | ELI LILLY AND COMPANY (US) | 1990-07-31 | — | — | US | disclosed |
| EP-0276065-B1 | ANTI-INFLAMMATORY AGENTS | ELI LILLY AND COMPANY (US) | 1990-06-06 | — | — | EP | disclosed |