Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417829 | 0.87 | HMGCR (0.54) | PDE4BCYP3A4KMT2AHTT | |
| SCHEMBL8893882 | 0.80 | HMGCR (0.56) | STING1CYP3A4KMT2AHTTTAAR1 | |
| SCHEMBL8902437 | 0.79 | KDM4E (0.53) | MAPK1CYP3A4KMT2ATAAR1 | |
| SCHEMBL14525269 | 0.78 | TAAR1 (0.51) | STING1CYP3A4KMT2ATAAR1 | |
| SCHEMBL14525270 | 0.78 | HPGDS (0.47) | STING1CYP3A4KMT2ATAAR1 | |
| SCHEMBL31113388 | 0.77 | HTT (0.53) | STING1CYP3A4KMT2AHTT | |
| SCHEMBL7261534 | 0.76 | PDE4B (0.60) | PDE4BMAPK1KMT2AHTT | |
| SCHEMBL8824020 | 0.75 | HMGCR (0.54) | PDE4BPOLBMAPK1SMN1; SMN2CYP3A4 | |
| SCHEMBL11836438 | 0.75 | STING1 (0.57) | STING1HTR4HTT | |
| SCHEMBL14925385 | 0.75 | TSHR (0.54) | PDE4BSMN1; SMN2HDAC8HDAC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294613-A | Benzene derivatives of p-substituted ether and acid or ester | ELI LILLY AND COMPANY (US) | 1994-03-15 | — | — | US | disclosed |
| US-5098613-A | Aromatic ethers for treatment of mammals | ELI LILLY AND COMPANY (US) | 1992-03-24 | — | — | US | disclosed |
| US-4945099-A | LEUKOTRIENE ANTAGONIST | ELI LILLY AND COMPANY (US) | 1990-07-31 | — | — | US | disclosed |
| EP-0276065-B1 | ANTI-INFLAMMATORY AGENTS | ELI LILLY AND COMPANY (US) | 1990-06-06 | — | — | EP | disclosed |
| EP-0276065-A1 | Anti-inflammatory agents | ELI LILLY AND COMPANY (US) | 1988-07-27 | — | — | EP | disclosed |