SCHEMBL9419225

SCHEMBL9419225

N=C(N)NCCC[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O

nearest known ligand 0.55

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ NPY4R P50391 12/20 0.55
▸ NPY1R P25929 7/20 0.55
▸ NPY2R P49146 5/20 0.55
▸ NPY5R Q15761 5/20 0.55
▸ OPRM1 P35372 2/20 0.46
▸ OPRD1 P41143 2/20 0.46
▸ MMP2 P08253 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31074747 1.00 NPY4R (0.55) NPY4RNPY1RNPY2RNPY5ROPRM1
SCHEMBL9419221 1.00 NPY4R (0.55) NPY4RNPY1RNPY2RNPY5ROPRM1
SCHEMBL13449160 0.97 NPY4R (0.60) NPY4RNPY1RNPY2RNPY5R
SCHEMBL29797028 0.96 NPY4R (0.52) NPY4RNPY1RNPY2RNPY5ROPRM1
SCHEMBL30082669 0.94 NPY4R (0.55) NPY4RNPY1RNPY2RNPY5ROPRM1
SCHEMBL30998029 0.94 NPY4R (0.55) NPY4RNPY1RNPY2RNPY5ROPRM1
SCHEMBL7594012 0.92 NPY4R (0.66) NPY4RNPY1RNPY2RNPY5ROPRM1
SCHEMBL7594031 0.92 NPY4R (0.66) NPY4RNPY1RNPY2RNPY5ROPRM1
SCHEMBL29531971 0.91 NPY4R (0.51) NPY4RNPY1RNPY2RNPY5ROPRM1
SCHEMBL30903436 0.91 NPY4R (0.51) NPY4RNPY1RNPY2RNPY5ROPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4347019-A1 MC3R AGONIST PEPTIDES The Regents Of The University Of Michigan (US) 2024-04-10 — — EP claimed
WO-2022251650-A1 MC3R AGONIST PEPTIDES THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2022-12-01 — — WO claimed
US-20240391954-A1 MC4R AGONIST PEPTIDES THE REGENTS OF THE UNIVERSITY OF MICHIGAN 2024-11-28 — — US disclosed
US-20240287154-A1 MC3R AGONIST PEPTIDES COURAGE THERAPEUTICS, INC. 2024-08-29 — — US disclosed
EP-4347019-A1 MC3R AGONIST PEPTIDES The Regents Of The University Of Michigan (US) 2024-04-10 — — EP disclosed
WO-2022251650-A1 MC3R AGONIST PEPTIDES THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2022-12-01 — — WO disclosed
US-20220133839-A1 PEPTIDE ANALOGUES WITH BRANCHED AMINO ACID PROBE(S) TXP PHARMA GMBH (CH) 2022-05-05 — — US disclosed
US-5354675-A Amidation of glycine SHISEIDO COMPANY LTD. (JP) 1994-10-11 — — US disclosed
EP-0447547-B1 C-TERMINUS AMIDATION ENZYME COMPOSITION, PROCESS FOR ITS PREPARATION AND ITS USE SHISEIDO CO LTD (JP) 1994-07-27 — — EP disclosed
EP-0447547-A1 C-TERMINUS AMIDATION ENZYME COMPOSITION, PROCESS FOR ITS PREPARATION AND ITS USE SHISEIDO COMPANY LIMITED (JP) 1991-09-25 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240287154-A1 MC3R AGONIST PEPTIDES MC3R, MC4R, MC1R NPY4R 15/4885NPY1R 19/4885NPY2R 27/4885
US-20240391954-A1 MC4R AGONIST PEPTIDES MC4R, MC3R, MC5R NPY4R 6/4885NPY1R 9/4885NPY2R 17/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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