SCHEMBL9420580

SCHEMBL9420580

COC(=O)CC(=O)CC(O)/C=C/c1ccccc1

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 1/20 0.41
TDP1 Q9NUW8 2/20 0.41
CYP1A2 P05177 1/20 0.41
ALDH1A1 P00352 2/20 0.40
AKT1 P31749 1/20 0.38
GLA P06280 1/20 0.38
EGFR P00533 2/20 0.37
APP P05067 1/20 0.37
MAPT P10636 1/20 0.37
HAO1 Q9UJM8 1/20 0.37
LMNA P02545 1/20 0.37
MMP1 P03956 1/20 0.37
MMP2 P08253 1/20 0.37
MMP9 P14780 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9420583 1.00 CNR2 (0.41) CNR2TDP1CYP1A2ALDH1A1AKT1
SCHEMBL8846258 0.87 TSHR (0.44) CNR2TDP1CYP1A2ALDH1A1EGFR
SCHEMBL8846251 0.87 TSHR (0.44) CNR2TDP1CYP1A2ALDH1A1EGFR
SCHEMBL9420682 0.86 HDAC3 (0.40) CNR2TDP1CYP1A2EGFR
SCHEMBL9420680 0.86 HDAC3 (0.40) CNR2TDP1CYP1A2EGFR
SCHEMBL17866582 0.84 CNR2 (0.45) CNR2CYP1A2ALDH1A1MAPTHAO1
SCHEMBL17866584 0.84 CNR2 (0.45) CNR2CYP1A2ALDH1A1MAPTHAO1
SCHEMBL17866583 0.84 CNR2 (0.45) CNR2CYP1A2ALDH1A1MAPTHAO1
SCHEMBL14163359 0.83 LMNA (0.50) CNR2TDP1ALDH1A1LMNAMMP9
SCHEMBL9420672 0.81 CNR2 (0.40) CNR2TDP1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5347039-A Process for the preparation of derivatives of 3,5-dihydroxypentanoic acid RHONE-POULENC RORER S.A. (FR) 1994-09-13 US disclosed