Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL20490076 | 0.96 | MEN1 (0.80) | — | |
| Choline SCHEMBL4958239 | 0.96 | — | — | |
| Choline SCHEMBL4958236 | 0.96 | — | — | |
| Choline SCHEMBL8012313 | 0.96 | MEN1 (0.92) | — | |
| Choline SCHEMBL16558587 | 0.96 | — | — | |
| Choline SCHEMBL29394392 | 0.96 | — | — | |
| Choline SCHEMBL14330721 | 0.96 | — | — | |
| Choline SCHEMBL300867 | 0.96 | MEN1 (0.92) | — | |
| Choline SCHEMBL13169639 | 0.96 | — | — | |
| Choline SCHEMBL17629823 | 0.96 | MEN1 (0.92) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612574-B2 | Ester blends for electric drive and cooling application | AURORIUM HOLDINGS LLC (US) | 2026-04-28 | — | — | US | disclosed |
| US-20250101331-A1 | ESTER BLENDS FOR ELECTRIC DRIVE AND COOLING APPLICATION | ANTARES CAPITAL LP, AS COLLATERAL AGENT | 2025-03-27 | — | — | US | disclosed |
| CN-114106043-A | Compound, preparation method thereof, method for preparing citicoline by compound and application | 成都海博为药业有限公司 | 2022-03-01 | — | — | CN | disclosed |
| CN-110169499-A | A kind of ewe full-valence pellet feed | 邳州市小河科技发展有限公司 | 2019-08-27 | — | — | CN | disclosed |
| CN-106083918-B | The preparation method of four hydrate of phosphoryl chloride choline calcium salt | 芜湖福民生物药业有限公司 | 2018-07-06 | — | — | CN | disclosed |
| CN-101967160-B | One-step method for preparing raceme DL, D or L-a-glycerin phosphorus acyl choline | CHANGSHU FUSHILAI MEDICINE & CHEMICAL CO LTD | 2013-04-10 | — | — | CN | disclosed |
| CN-101967160-A | One-step method for preparing raceme DL, D or L-a-glycerin phosphorus acyl choline | CHANGSHU FUSHILAI MEDICINE & CHEMICAL CO LTD | 2011-02-09 | — | — | CN | disclosed |
| CN-100360051-C | Density-enhanced pet food and method of making same | NESTEC SA (CH) | 2008-01-09 | — | — | CN | disclosed |
| CN-1705443-A | Increased density pet food product and method of production | NESTEC SA (CH) | 2005-12-07 | — | — | CN | disclosed |
| WO-1994018994-A1 | THERAPEUTIC HERBAL COMPOSITION | PHARMAKON USA, INC. (US) | 1994-09-01 | — | — | WO | disclosed |