Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL28574484 | 0.96 | CYP3A4 (1.00) | — | |
| Choline SCHEMBL29499824 | 0.96 | — | — | |
| Choline SCHEMBL1332010 | 0.96 | — | — | |
| Choline SCHEMBL9422357 | 0.96 | — | — | |
| Choline SCHEMBL9391204 | 0.96 | CYP3A4 (1.00) | — | |
| Choline SCHEMBL14957 | 0.96 | — | — | |
| Choline SCHEMBL2459999 | 0.96 | CYP3A4 (1.00) | — | |
| Choline SCHEMBL30612764 | 0.96 | — | — | |
| Choline SCHEMBL1330530 | 0.96 | — | — | |
| Choline SCHEMBL9141711 | 0.93 | CYP3A4 (0.93) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113816991-B | Preparation method of choline calcium chloride phosphate | 拓新药业集团股份有限公司 | 2023-12-15 | — | — | CN | claimed |
| CN-116768948-A | Method for synthesizing urine phosphorylcholine in citicoline injection | 山东玉满坤生物科技有限公司 | 2023-09-19 | — | — | CN | claimed |
| CN-116284187-A | Method for synthesizing urine phosphorylcholine in citicoline injection | 山东玉满坤生物科技有限公司 | 2023-06-23 | — | — | CN | claimed |
| CN-113816991-A | Preparation method of choline calcium phosphochloride | 新乡拓新药业股份有限公司 | 2021-12-21 | — | — | CN | claimed |
| CN-111808899-A | Synthesis method of citicoline sodium | 宁波酶赛生物工程有限公司 | 2020-10-23 | — | — | CN | claimed |
| CN-108101936-A | A kind of calcium removal methods of Phosphorylcholine calcium chloride | 中山百灵生物技术有限公司 | 2018-06-01 | — | — | CN | claimed |
| CN-108017665-A | A kind of preparation of L- α-choline glycerophosphatide and purification process | 湖南托阳制药有限公司 | 2018-05-11 | — | — | CN | claimed |
| CN-107383085-A | A kind of chemical synthesis process of L α Choline Glycerophosphates | 湖南托阳制药有限公司 | 2017-11-24 | — | — | CN | claimed |
| CN-119955879-A | Method for synthesizing citicoline by biological enzyme | 拓新药业集团股份有限公司 | 2025-05-09 | — | — | CN | disclosed |
| CN-113816991-B | Preparation method of choline calcium chloride phosphate | 拓新药业集团股份有限公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-113816991-B | Preparation method of choline calcium chloride phosphate | 拓新药业集团股份有限公司 | 2023-12-15 | — | — | CN | disclosed |
| CN-116768948-A | Method for synthesizing urine phosphorylcholine in citicoline injection | 山东玉满坤生物科技有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-116768948-A | Method for synthesizing urine phosphorylcholine in citicoline injection | 山东玉满坤生物科技有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-116284187-A | Method for synthesizing urine phosphorylcholine in citicoline injection | 山东玉满坤生物科技有限公司 | 2023-06-23 | — | — | CN | disclosed |
| US-6926917-B2 | Dry pet food with increased palatability and method of production | NESTEC LTD. (CH) | 2005-08-09 | — | — | US | disclosed |
| WO-2004034812-A1 | DRY PET FOOD WITH INCREASED PALATABILITY AND METHOD OF PRODUCTION | NESTEC S.A. (CH) | 2004-04-29 | — | — | WO | disclosed |
| WO-2004034811-A1 | INCREASED DENSITY PET FOOD PRODUCT AND METHOD OF PRODUCTION | NESTEC S.A. (CH) | 2004-04-29 | — | — | WO | disclosed |
| US-20040076718-A1 | Dry pet food with increased palatability and method of production | NESTEC, LTD. (CH) | 2004-04-22 | — | — | US | disclosed |
| US-20040076715-A1 | Increased density pet food product and method of production | NESTEC, LTD. (CH) | 2004-04-22 | — | — | US | disclosed |
| CN-1104890-A | Cation-complexed polysacharides | HERCULES INC (US) | 1995-07-12 | — | — | CN | disclosed |