SCHEMBL9422452

SCHEMBL9422452

CSCC(C)OC(=O)c1cc(N=c2sc(=O)n3n2CCCC3)c(F)cc1Cl

nearest known ligand 0.58

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.37
SMN1; SMN2 Q16637 2/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
ALDH1A1 P00352 1/20 0.32
USP2 O75604 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9493042 1.00 HPGD (0.37) HPGDSMN1; SMN2LMNAMAPTALDH1A1
SCHEMBL9493857 0.94 HPGD (0.36) HPGDSMN1; SMN2LMNAMAPTALDH1A1
SCHEMBL9493861 0.94 HPGD (0.36) HPGDSMN1; SMN2LMNAMAPTALDH1A1
SCHEMBL9492161 0.92 HPGD (0.37) HPGDSMN1; SMN2LMNAMAPTALDH1A1
SCHEMBL9492159 0.92 HPGD (0.37) HPGDSMN1; SMN2LMNAMAPTALDH1A1
SCHEMBL9492294 0.91 HPGD (0.35) HPGDSMN1; SMN2LMNAMAPTALDH1A1
SCHEMBL9492292 0.91 HPGD (0.35) HPGDSMN1; SMN2LMNAMAPTALDH1A1
SCHEMBL9494147 0.89 HPGD (0.33) HPGDSMN1; SMN2LMNAMAPT
SCHEMBL9491324 0.89 HPGD (0.39) HPGDSMN1; SMN2LMNAMAPTALDH1A1
SCHEMBL9494145 0.89 HPGD (0.33) HPGDSMN1; SMN2LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0457714-A1 Thiadiazabicyclononane derivatives, process for their preparation, intermediates and their use as herbicides CIBA-GEIGY AG (CH) 1991-11-21 EP claimed
JP-6056847-A None JP disclosed
JP-H0656847-A NEW HERBICIDE CIBA GEIGY AG 1994-03-01 JP disclosed
US-5229514-A Thiourea compounds containing pyridazine ring CIBA-GEIGY CORPORATION (US) 1993-07-20 US disclosed
US-5135562-A 8-thia-1,6-diazabicyclo[4.3.0]nonane herbicides CIBA-GEIGY CORPORATION (US) 1992-08-04 US disclosed
EP-0457714-A1 Thiadiazabicyclononane derivatives, process for their preparation, intermediates and their use as herbicides CIBA-GEIGY AG (CH) 1991-11-21 EP disclosed