Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9423913 | 1.00 | SMN1; SMN2 (0.55) | SMN1; SMN2NPSR1LMNAKMT2APLA2G1B | |
| SCHEMBL9059067 | 0.96 | SMN1; SMN2 (0.50) | SMN1; SMN2NPSR1LMNAKMT2APLA2G1B | |
| SCHEMBL9059065 | 0.96 | SMN1; SMN2 (0.50) | SMN1; SMN2NPSR1LMNAKMT2APLA2G1B | |
| SCHEMBL9424269 | 0.91 | LMNA (0.46) | SMN1; SMN2NPSR1LMNAKMT2AALDH1A1 | |
| SCHEMBL9424270 | 0.91 | LMNA (0.46) | SMN1; SMN2NPSR1LMNAKMT2AALDH1A1 | |
| SCHEMBL9059307 | 0.89 | SMN1; SMN2 (0.45) | SMN1; SMN2NPSR1LMNAKMT2APLA2G1B | |
| SCHEMBL9059309 | 0.89 | SMN1; SMN2 (0.45) | SMN1; SMN2NPSR1LMNAKMT2APLA2G1B | |
| SCHEMBL9424743 | 0.86 | SMN1; SMN2 (0.43) | SMN1; SMN2NPSR1LMNAKMT2ATSHR | |
| SCHEMBL9424747 | 0.86 | SMN1; SMN2 (0.43) | SMN1; SMN2NPSR1LMNAKMT2ATSHR | |
| SCHEMBL9424111 | 0.81 | SMN1; SMN2 (0.47) | SMN1; SMN2NPSR1LMNAKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373008-A | Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents | THE BOOTS COMPANT PLC. (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5223498-A | Hypoglycemic agents | THE BOOTS COMPANY PLC (GB) | 1993-06-29 | — | — | US | disclosed |
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | disclosed |
| EP-0385038-A1 | Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them | The Boots Company PLC (GB) | 1990-09-05 | — | — | EP | disclosed |