Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.44 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.38 |
| ▸ | KDM5C | P41229 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.38 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31310487 | 0.98 | EPHX2 (0.54) | EPHX2ALDH1A1DNM1S1PR2S1PR1 | |
| SCHEMBL23161586 | 0.98 | EPHX2 (0.54) | EPHX2ALDH1A1DNM1S1PR2S1PR1 | |
| SCHEMBL9424278 | 0.93 | ALDH1A1 (0.46) | EPHX2ALDH1A1DNM1CES2CES1 | |
| SCHEMBL10816873 | 0.90 | EPHX2 (0.59) | EPHX2ALDH1A1DNM1S1PR2S1PR1 | |
| Phosphoric Acid SCHEMBL28272112 | 0.90 | S1PR2 (0.50) | EPHX2DNM1S1PR2S1PR1S1PR3 | |
| SCHEMBL11634642 | 0.88 | EPHX2 (0.62) | EPHX2ALDH1A1DNM1S1PR2S1PR1 | |
| SCHEMBL11046710 | 0.88 | EPHX2 (0.62) | EPHX2ALDH1A1DNM1S1PR2S1PR1 | |
| SCHEMBL20625249 | 0.88 | EPHX2 (0.62) | EPHX2ALDH1A1DNM1S1PR2S1PR1 | |
| SCHEMBL29407141 | 0.88 | EPHX2 (0.62) | EPHX2ALDH1A1DNM1S1PR2S1PR1 | |
| SCHEMBL19570768 | 0.85 | EPHX2 (0.45) | EPHX2ALDH1A1DNM1S1PR2S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7696177-B2 | Anti-hypercholesterolemic compounds | MERCK SHARP & DOHME CORP. (US) | 2010-04-13 | — | — | US | disclosed |
| US-20100004184-A1 | Anti-hypercholesterolemic compounds | MERCK SHARP & DOHME CORP. | 2010-01-07 | — | — | US | disclosed |
| US-5373008-A | Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents | THE BOOTS COMPANT PLC. (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5223498-A | Hypoglycemic agents | THE BOOTS COMPANY PLC (GB) | 1993-06-29 | — | — | US | disclosed |
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | disclosed |
| EP-0385038-A1 | Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them | The Boots Company PLC (GB) | 1990-09-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004184-A1 | Anti-hypercholesterolemic compounds | PCSK9, SLC10A1, NPC1 | EPHX2 2046/4885ALDH1A1 1283/4885DNM1 1070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.