Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9423977 | 1.00 | ALDH1A1 (0.43) | ALDH1A1LMNASMN1; SMN2HPGDPRKDC | |
| Hydrochloric Acid SCHEMBL9424435 | 0.99 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2HPGDPRKDC | |
| Hydrochloric Acid SCHEMBL9424436 | 0.99 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2HPGDPRKDC | |
| SCHEMBL9424333 | 0.90 | ALDH1A1 (0.40) | ALDH1A1LMNASMN1; SMN2HPGDPRKDC | |
| SCHEMBL9424332 | 0.90 | ALDH1A1 (0.40) | ALDH1A1LMNASMN1; SMN2HPGDPRKDC | |
| SCHEMBL9059425 | 0.86 | NPC1 (0.36) | ALDH1A1LMNASMN1; SMN2HPGDPRKDC | |
| SCHEMBL9059423 | 0.86 | NPC1 (0.36) | ALDH1A1LMNASMN1; SMN2HPGDPRKDC | |
| SCHEMBL9424392 | 0.86 | AKR1C3 (0.46) | ALDH1A1LMNASMN1; SMN2HPGDPRKDC | |
| SCHEMBL9424300 | 0.86 | ALDH1A1 (0.40) | ALDH1A1LMNASMN1; SMN2HPGDMAPT | |
| SCHEMBL9424397 | 0.86 | AKR1C3 (0.46) | ALDH1A1LMNASMN1; SMN2HPGDPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5223498-A | Hypoglycemic agents | THE BOOTS COMPANY PLC (GB) | 1993-06-29 | — | — | US | claimed |
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | claimed |
| EP-0385038-A1 | Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them | The Boots Company PLC (GB) | 1990-09-05 | — | — | EP | claimed |
| CN-1037346-C | Therapeutic agents | BOOTS CO LTD (GB) | 1998-02-11 | — | — | CN | disclosed |
| US-5373008-A | Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents | THE BOOTS COMPANT PLC. (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5223498-A | Hypoglycemic agents | THE BOOTS COMPANY PLC (GB) | 1993-06-29 | — | — | US | disclosed |
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | disclosed |
| CN-1057648-A | Therapeutical agent | BOOTS CO PLC (GB) | 1992-01-08 | — | — | CN | disclosed |
| EP-0385038-A1 | Ortho-substituted phenyl amidine and phenyl guanidine derivatives and antidiabetic or hypoglycaemic agents containing them | The Boots Company PLC (GB) | 1990-09-05 | — | — | EP | disclosed |