Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9424193 | 1.00 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDLMNAALOX15 | |
| SCHEMBL9059387 | 0.98 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDLMNAALOX15 | |
| SCHEMBL9424675 | 0.98 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDLMNAALOX15 | |
| SCHEMBL9424678 | 0.98 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDLMNAALOX15 | |
| SCHEMBL9424033 | 0.97 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDLMNAALOX15 | |
| SCHEMBL9424031 | 0.97 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDLMNAALOX15 | |
| SCHEMBL9059117 | 0.95 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDLMNAALOX15 | |
| SCHEMBL9059118 | 0.95 | ALDH1A1 (0.51) | ALDH1A1KDM4EHPGDLMNAALOX15 | |
| SCHEMBL9063207 | 0.90 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDLMNAALOX15 | |
| SCHEMBL9059573 | 0.90 | ALDH1A1 (0.47) | ALDH1A1KDM4EHPGDLMNAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5373008-A | Phenylamidine and phenylguanidine derivatives and their use as anti-diabetic agents | THE BOOTS COMPANT PLC. (GB) | 1994-12-13 | — | — | US | disclosed |
| US-5223498-A | Hypoglycemic agents | THE BOOTS COMPANY PLC (GB) | 1993-06-29 | — | — | US | disclosed |
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | disclosed |