Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | CETP | P11597 | 3/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4115633 | 0.87 | TSHR (0.59) | TSHRCETPFOLH1RAB9ANPC1 | |
| SCHEMBL7368155 | 0.81 | MEN1 (0.50) | PTPN1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL10711859 | 0.74 | TSHR (0.54) | TSHRCETPPTPN1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL28311600 | 0.74 | TSHR (0.54) | TSHRCETPPTPN1MEN1KMT2A | |
| SCHEMBL4116938 | 0.74 | TSHR (0.54) | TSHRCETPMEN1KMT2AFOLH1 | |
| SCHEMBL15707660 | 0.74 | TSHR (0.46) | TSHRCETPPTPN1KCNN4MEN1 | |
| SCHEMBL2659137 | 0.73 | PTPN1 (0.55) | TSHRCETPPTPN1KMT2AALDH1A1 | |
| SCHEMBL7685660 | 0.72 | CETP (0.49) | TSHRCETPPTPN1MEN1KMT2A | |
| SCHEMBL11333838 | 0.72 | TSHR (0.56) | TSHRCETPFOLH1RAB9ANPC1 | |
| SCHEMBL20701826 | 0.72 | TSHR (0.79) | TSHRCETPPTPN1FOLH1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5312828-A | Substituted imidazoles having angiotensin II receptor blocking activity | SMITHKLINE BEECHAM CORPORATION A CORP. OF PENNSYLVANIA | 1994-05-17 | — | — | US | disclosed |
| EP-0403158-A2 | Imidazolyl-alkenoic acids | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-19 | — | — | EP | disclosed |