Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.84 |
| ▸ | NPC1 | O15118 | 2/20 | 0.84 |
| ▸ | MEN1 | O00255 | 2/20 | 0.84 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.84 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.84 |
| ▸ | RAB9A | P51151 | 1/20 | 0.84 |
| ▸ | APP | P05067 | 5/20 | 0.70 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.69 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.60 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.60 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.59 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9425402 | 1.00 | MAPT (0.84) | MAPTNPC1MEN1MAPK1KMT2A | |
| SCHEMBL634358 | 0.92 | MAPT (1.00) | MAPTNPC1MEN1MAPK1KMT2A | |
| SCHEMBL634357 | 0.92 | MAPT (1.00) | MAPTNPC1MEN1MAPK1KMT2A | |
| SCHEMBL28681178 | 0.89 | MAPT (0.95) | MAPTNPC1MEN1MAPK1KMT2A | |
| SCHEMBL7634371 | 0.87 | MAPT (0.77) | MAPTNPC1MEN1MAPK1KMT2A | |
| SCHEMBL14769357 | 0.86 | MAPT (0.80) | MAPTNPC1MEN1MAPK1KMT2A | |
| SCHEMBL25212956 | 0.83 | APP (0.80) | MAPTNPC1MEN1MAPK1KMT2A | |
| SCHEMBL4786710 | 0.83 | APP (0.80) | MAPTNPC1MEN1MAPK1KMT2A | |
| SCHEMBL9112510 | 0.83 | TNFRSF1A (0.80) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL9112505 | 0.83 | TNFRSF1A (0.80) | MAPTNPC1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278184-A | Synthetic derivatives of pyrrole and pyrrolidine suitable for the therapy of infections caused by rhinoviruses | REPLA CHEMICAL LTD. (LI) | 1994-01-11 | — | — | US | disclosed |
| EP-0509469-A1 | Synthetic compounds suitable for the therapy of infections caused by rhinoviruses | REPLA CHEMICAL LTD. (LI) | 1992-10-21 | — | — | EP | disclosed |