Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.80 |
| ▸ | NPC1 | O15118 | 3/20 | 0.80 |
| ▸ | MEN1 | O00255 | 3/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.80 |
| ▸ | RAB9A | P51151 | 2/20 | 0.80 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.80 |
| ▸ | APP | P05067 | 3/20 | 0.67 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.58 |
| ▸ | PDE4A | P27815 | 1/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.57 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL634357 | 0.89 | MAPT (1.00) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL634358 | 0.89 | MAPT (1.00) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL28681178 | 0.87 | MAPT (0.95) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL9425399 | 0.86 | MAPT (0.84) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL9425402 | 0.86 | MAPT (0.84) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL28390756 | 0.83 | MAPT (0.82) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL28390757 | 0.83 | MAPT (0.82) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL2462050 | 0.82 | MAPT (1.00) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL2462049 | 0.82 | MAPT (1.00) | MAPTNPC1MEN1KMT2ARAB9A | |
| SCHEMBL632910 | 0.82 | MAPT (0.81) | MAPTNPC1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9101600-B2 | Compounds as RORγt modulators and uses thereof | NEW YORK UNIVERSITY (US) | 2015-08-11 | — | — | US | disclosed |
| US-20130065842-A1 | COMPOUNDS AS RORyT MODULATORS AND USES THEREOF | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130065842-A1 | COMPOUNDS AS RORyT MODULATORS AND USES THEREOF | RORC, RORB, RORA | MAPT 3323/4885NPC1 1496/4885MEN1 2318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.