Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | MYC | P01106 | 2/20 | 0.44 |
| ▸ | WDR5 | P61964 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5171580 | 0.85 | CYP3A4 (0.48) | MYCWDR5NOS1FBP1CDK2 | |
| SCHEMBL15587224 | 0.81 | MYC (0.47) | MYCWDR5NOS1CDK2CSNK2A1 | |
| SCHEMBL9048249 | 0.80 | NOS1 (0.46) | MYCWDR5NOS1DHFRCDK2 | |
| SCHEMBL9426921 | 0.78 | POLB (0.51) | MYCWDR5DHFRFBP1ALDH1A1 | |
| SCHEMBL9098198 | 0.78 | MYC (0.59) | MYCWDR5GAANOS1CDK2 | |
| SCHEMBL1060492 | 0.76 | MAPT (0.54) | MYCWDR5GAAMGAMSI | |
| SCHEMBL9426820 | 0.76 | GAA (0.42) | GAACDK2HTTL3MBTL1ALDH1A1 | |
| SCHEMBL28443457 | 0.75 | SMN1; SMN2 (0.45) | MYCWDR5DHFRHTTALDH1A1 | |
| SCHEMBL2907382 | 0.75 | GCK (0.41) | MYCWDR5CDK2 | |
| SCHEMBL29932940 | 0.75 | MCL1 (0.48) | CSNK2A1HTTALDH1A1CYP3A4THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5369107-A | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-29 | — | — | US | disclosed |
| US-5256675-A | Antirheumatic agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-10-26 | — | — | US | disclosed |
| CN-1049337-A | Thiazole derivative prepares their method, and the medicinal compositions that contains them | FUJISAWA PHARMACEUTICAL CO (JP) | 1991-02-20 | — | — | CN | disclosed |
| EP-0412404-A2 | Thiazole derivatives, processes for production thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-13 | — | — | EP | disclosed |