Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | GNRHR | P30968 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6055037 | 0.78 | MEN1 (0.53) | HSP90AA1CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL7280887 | 0.75 | MEN1 (0.55) | — | |
| SCHEMBL8902416 | 0.75 | MAPT (0.57) | — | |
| SCHEMBL11466925 | 0.72 | CHRNB4 (0.54) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL6560708 | 0.71 | MAPT (0.56) | — | |
| SCHEMBL4201146 | 0.70 | MAPK1 (0.54) | CHRNB4CHRNA3CHEK1 | |
| SCHEMBL11466376 | 0.70 | CHRNB4 (0.51) | HSP90AA1HSP90AB1CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL11456174 | 0.70 | CHRNB4 (0.74) | CHRNB4CHRNA3CHRNB2CHRNA4CHEK1 | |
| SCHEMBL7290977 | 0.70 | POLB (0.52) | — | |
| SCHEMBL5152693 | 0.70 | CHRNB4 (0.55) | CHRNB4CHRNA3CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5306818-A | Treating degenerative diseases such as emphysema, rheumatoid arthritis and pancreatitis | STERLING WINTHROP INC. (US) | 1994-04-26 | — | — | US | disclosed |