Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8902416 | 0.96 | MAPT (0.57) | MAPTCHEK2RAB9AKDM4ETDP1 | |
| SCHEMBL6765314 | 0.88 | CHEK2 (0.52) | MAPTCHEK2RAB9ATDP1L3MBTL1 | |
| SCHEMBL3866051 | 0.86 | CHEK2 (0.56) | CHEK2MEN1KMT2AHRH2HRH1 | |
| SCHEMBL5706378 | 0.85 | CHEK2 (0.55) | CHEK2HRH2HRH1LTA4H | |
| Hydrochloric Acid SCHEMBL6561583 | 0.85 | CHEK2 (0.55) | CHEK2MEN1KMT2AHRH2HRH1 | |
| SCHEMBL6004777 | 0.84 | CHEK2 (0.54) | CHEK2HRH2HRH1LTA4H | |
| Hydrochloric Acid SCHEMBL6560096 | 0.84 | CHEK2 (0.54) | CHEK2HRH2HRH1LTA4H | |
| SCHEMBL3864926 | 0.83 | CHEK2 (0.50) | CHEK2HRH2HRH1LTA4H | |
| SCHEMBL5155424 | 0.83 | LTA4H (0.58) | MAPTLTA4H | |
| SCHEMBL11449154 | 0.83 | LTA4H (0.50) | CHEK2KDM4ELTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1395563-A1 | 2-SUBSTITUTED 1,2,3,4-TETRAHYDROQUINOLINES AND DERIVATIVES THEREOF, COMPOSITIONS AND METHODS | ELI LILLY AND COMPANY (US) | 2004-03-10 | — | — | EP | disclosed |
| WO-2002094788-A1 | 2-SUBSTITUTED 1,2,3,4-TETRAHYDROQUINOLINES AND DERIVATIVES THEREOF, COMPOSITIONS AND METHODS | ELI LILLY AND COMPANY (US) | 2002-11-28 | — | — | WO | disclosed |