Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.67 |
| ▸ | RAB9A | P51151 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ALOX5 | P09917 | 9/20 | 0.64 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8626714 | 0.85 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL8626737 | 0.85 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL8622647 | 0.84 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL8622668 | 0.84 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL9427951 | 0.84 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| 2-(Phenoxymethyl)Benzothiazole SCHEMBL2245843 | 0.81 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL9564300 | 0.81 | ALOX5 (0.67) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL9590136 | 0.81 | ALOX5 (0.57) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL9585158 | 0.81 | ALOX5 (0.57) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 | |
| SCHEMBL8769691 | 0.79 | EPHX2 (0.84) | NPC1RAB9ASMN1; SMN2L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5364944-A | Antiinflammatory, antiallergic and cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-11-15 | — | — | US | disclosed |
| US-5218124-A | Antiinflammatory agents, antiallergens and cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-06-08 | — | — | US | disclosed |
| US-5071988-A | Antiu lcer agents, antiallergens cytoprotective agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-12-10 | — | — | US | disclosed |