Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.51 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9427557 | 0.92 | AGTR1 (0.49) | AGTR1AGTR2ACHESLC6A3SLC6A4 | |
| SCHEMBL9427961 | 0.92 | AGTR1 (0.51) | AGTR1AGTR2ACHESLC6A3SLC6A4 | |
| SCHEMBL9457437 | 0.89 | MEN1 (0.43) | AGTR1AGTR2 | |
| SCHEMBL9427852 | 0.88 | PPARG (0.58) | AGTR1AGTR2PPARG | |
| SCHEMBL9428006 | 0.88 | AGTR1 (0.49) | AGTR1AGTR2ACHESLC6A3SLC6A4 | |
| SCHEMBL9427632 | 0.86 | AGTR1 (0.54) | AGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL9428062 | 0.86 | AGTR1 (0.49) | AGTR1AGTR2ACHESLC6A3SLC6A4 | |
| SCHEMBL9429975 | 0.85 | SMN1; SMN2 (0.55) | AGTR1AGTR2ACHESLC6A3SLC6A4 | |
| SCHEMBL9427496 | 0.85 | AGTR1 (0.49) | AGTR1AGTR2ACHESLC6A3SLC6A4 | |
| SCHEMBL9428305 | 0.84 | AGTR1 (0.54) | AGTR1AGTR2ACHELTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310179-A2 | Tetrahydrocarbazole esters | MERCK FROSST CANADA INC. (CA) | 1989-04-05 | — | — | EP | claimed |
| US-5315013-A | Hypotensive | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-05-24 | — | — | US | disclosed |
| EP-0323841-B1 | SUBSTITUTED PYRROLE, PYRAZOLE AND TRIAZOLE ANGIOTENSIN II ANTAGONISTS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-08-04 | — | — | EP | disclosed |
| US-5189048-A | Hypotensive agents | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-02-23 | — | — | US | disclosed |
| US-5093346-A | Hypotensive agents, congestive heart failure | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-03-03 | — | — | US | disclosed |
| US-5081127-A | Hypotensive agents and treatment of congestive heart failure | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-01-14 | — | — | US | disclosed |
| US-5043349-A | Hypotensive agents, treatment of congestive heart failure | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-08-27 | — | — | US | disclosed |
| US-5015651-A | Triazole derivatives for treatment of congestive heart failure | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-05-14 | — | — | US | disclosed |
| EP-0323841-A2 | Substituted pyrrole, pyrazole and triazole angiotensin II antagonists | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-12 | — | — | EP | disclosed |