Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 10/20 | 0.50 |
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | BID | P55957 | 3/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.41 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9428519 | 0.95 | POLB (0.49) | CYSLTR2CYSLTR1POLB | |
| SCHEMBL9428107 | 0.90 | CYSLTR2 (0.62) | CYSLTR2CYSLTR1POLBBIDMCL1 | |
| SCHEMBL9856022 | 0.90 | CYSLTR2 (0.62) | CYSLTR2CYSLTR1POLBBIDMCL1 | |
| SCHEMBL9428987 | 0.86 | CYSLTR2 (0.57) | CYSLTR2CYSLTR1POLBBIDMCL1 | |
| SCHEMBL9429047 | 0.81 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1POLBBIDMCL1 | |
| SCHEMBL10436550 | 0.78 | POLB (0.56) | POLBPPARA | |
| SCHEMBL9428584 | 0.77 | POLB (0.55) | POLBPLK1 | |
| SCHEMBL9395596 | 0.77 | CYSLTR2 (0.81) | CYSLTR2CYSLTR1 | |
| SCHEMBL9395589 | 0.77 | CYSLTR2 (0.81) | CYSLTR2CYSLTR1 | |
| SCHEMBL27262084 | 0.77 | CYSLTR2 (0.81) | CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5314918-A | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1994-05-24 | — | — | US | disclosed |
| EP-0296732-B1 | LEUKOTRIENE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-09 | — | — | EP | disclosed |
| EP-0403249-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-19 | — | — | EP | disclosed |
| EP-0296732-A1 | Leukotriene antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1988-12-28 | — | — | EP | disclosed |