Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | PRF1 | P14222 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 9/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | NPC1 | O15118 | 8/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18832290 | 0.83 | PRF1 (0.54) | CYP1A2LMNACYP3A4MAOAPRF1 | |
| SCHEMBL5204528 | 0.82 | PRF1 (0.56) | CYP1A2LMNACYP3A4MAOAPRF1 | |
| SCHEMBL3772607 | 0.78 | CSNK2A1 (0.62) | CYP1A2LMNACYP3A4MAOACA1 | |
| SCHEMBL5207670 | 0.78 | PRF1 (0.56) | CYP1A2LMNACYP3A4MAOAPRF1 | |
| SCHEMBL16351874 | 0.78 | CA1 (0.73) | CYP1A2LMNACYP3A4MAOACA1 | |
| SCHEMBL1965326 | 0.78 | CA1 (0.73) | CYP1A2LMNACYP3A4MAOACA1 | |
| SCHEMBL11374568 | 0.77 | LMNA (0.89) | CYP1A2LMNACYP3A4MAOACA1 | |
| SCHEMBL5556244 | 0.77 | CA12 (0.66) | CYP1A2LMNACYP3A4MAOACA1 | |
| SCHEMBL87450 | 0.76 | CA1 (0.83) | CYP1A2LMNACYP3A4MAOACA1 | |
| SCHEMBL2028546 | 0.76 | MAPT (0.62) | CYP1A2LMNACYP3A4MAOARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328907-A | Treatment of allograft rejection in mammals and antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1994-07-12 | — | — | US | disclosed |
| US-5108999-A | For treating inflammation, autoimmune disease or allograft rejection in mammals | SYNTEX (U.S.A.) INC. (US) | 1992-04-28 | — | — | US | disclosed |
| EP-0440503-A1 | 4-Isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-08-07 | — | — | EP | disclosed |
| US-5001124-A | 4-isoxazolecarboxamide derivatives | SYNTEX (U.S.A.) INC. (US) | 1991-03-19 | — | — | US | disclosed |