Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 9/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL941582 | 0.94 | CMA1 (0.50) | CMA1MAOBRAB9ANPC1KMT2A | |
| SCHEMBL942502 | 0.88 | CMA1 (0.63) | CMA1MAOBRAB9ANPC1KMT2A | |
| SCHEMBL944661 | 0.88 | CMA1 (0.53) | CMA1MAOBRAB9ANPC1KMT2A | |
| SCHEMBL942532 | 0.87 | CMA1 (0.52) | CMA1MAOBRAB9ANPC1KMT2A | |
| SCHEMBL941825 | 0.87 | CMA1 (0.52) | CMA1MAOBRAB9ANPC1KMT2A | |
| SCHEMBL941589 | 0.83 | CMA1 (0.45) | CMA1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL943069 | 0.81 | CMA1 (0.77) | CMA1MAOBRAB9ANPC1KMT2A | |
| SCHEMBL942971 | 0.80 | CMA1 (0.66) | CMA1MAOBRAB9ANPC1KMT2A | |
| SCHEMBL943094 | 0.80 | CMA1 (0.40) | CMA1RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL942684 | 0.78 | CMA1 (0.50) | CMA1MAOBRAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7872044-B2 | (thio)amide benzofuran compounds containing phosphonic, phosphinic, sulfonic, sulfamic, or carboxy acid groups; for example [benzofuran-3-yl-(naphthalen-2-ylcarbamoyl)-methyl]-phosphonic acid; treating inflammatory or serine protease mediated disorders such as allergic rhinitis, asthma and heart failure | JANSSEN PHARMACEUTICA NV (BE) | 2011-01-18 | — | — | US | claimed |
| EP-2097399-A2 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-09-09 | — | — | EP | claimed |
| US-20080096844-A1 | Novel inhibitors of chymase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-04-24 | — | — | US | claimed |
| WO-2008048668-A2 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-04-24 | — | — | WO | claimed |
| EP-2097399-A2 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-09-09 | — | — | EP | disclosed |
| US-20080096844-A1 | Novel inhibitors of chymase | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-04-24 | — | — | US | disclosed |
| WO-2008048668-A2 | NOVEL INHIBITORS OF CHYMASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096844-A1 | Novel inhibitors of chymase | CMA1, SERPINB1, PRSS1 | CMA1 1/4885MAOB 899/4885RAB9A 1071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.