Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9430908 | 0.84 | CHRNA7 (0.49) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9431318 | 0.81 | CHRNA7 (0.49) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| Oxalic Acid SCHEMBL9677370 | 0.80 | CHRNA7 (0.45) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8961518 | 0.77 | CHRNA7 (0.41) | CHRNA7 | |
| SCHEMBL9431645 | 0.77 | CHRNA7 (0.45) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9431123 | 0.77 | CHRNA7 (0.45) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9431139 | 0.74 | CHRNA7 (0.42) | CHRNA7 | |
| SCHEMBL9431132 | 0.73 | CHRNA7 (0.56) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL6345310 | 0.73 | CHRNA7 (0.51) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| Oxalic Acid SCHEMBL9676174 | 0.71 | FFAR4 (0.42) | CHRNA7CHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412798-A2 | Substituted pyridines, their preparation, formulations and use in dementia | MERCK SHARP & DOHME LTD. (GB) | 1991-02-13 | — | — | EP | claimed |
| US-5346906-A | Enhancement of cholinergic transmitters in treatment of neurological and mental disorders such as Alzheimer's | MERCK SHARPE & DOHME LTD. (GB) | 1994-09-13 | — | — | US | disclosed |
| EP-0412798-A2 | Substituted pyridines, their preparation, formulations and use in dementia | MERCK SHARP & DOHME LTD. (GB) | 1991-02-13 | — | — | EP | disclosed |