Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 10/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.61 |
| ▸ | CHRM4 | P08173 | 8/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 8/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9458775 | 0.79 | KMT2A (0.52) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9431134 | 0.79 | CHRM1 (0.56) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9430809 | 0.76 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL15448102 | 0.72 | CHRM1 (0.55) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9342940 | 0.71 | CHRM1 (0.51) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9342094 | 0.71 | CHRM1 (0.52) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9489707 | 0.70 | CHRM1 (0.56) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9458720 | 0.69 | KMT2A (0.62) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL7398171 | 0.68 | CHRM1 (0.59) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL7920314 | 0.68 | CHRM1 (0.54) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412798-A2 | Substituted pyridines, their preparation, formulations and use in dementia | MERCK SHARP & DOHME LTD. (GB) | 1991-02-13 | — | — | EP | claimed |
| US-5346906-A | Enhancement of cholinergic transmitters in treatment of neurological and mental disorders such as Alzheimer's | MERCK SHARPE & DOHME LTD. (GB) | 1994-09-13 | — | — | US | disclosed |
| EP-0412798-A2 | Substituted pyridines, their preparation, formulations and use in dementia | MERCK SHARP & DOHME LTD. (GB) | 1991-02-13 | — | — | EP | disclosed |