Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 7/20 | 0.66 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.66 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.66 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.66 |
| ▸ | HTR3A | P46098 | 4/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9430809 | 0.79 | CHRM1 (1.00) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL9430920 | 0.73 | CHRM2 (0.44) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL9432547 | 0.72 | CHRM2 (0.43) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL9632990 | 0.71 | KDM1A (0.40) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL9225450 | 0.71 | CHRM2 (0.37) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL9458894 | 0.71 | HTR3A (0.43) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL9459215 | 0.69 | HTR3A (0.39) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL9458887 | 0.68 | HTR3A (0.44) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL14808736 | 0.68 | CHRM2 (0.52) | CHRM2CHRM3CHRM4CHRM5CHRM1 | |
| SCHEMBL9229628 | 0.67 | CHRM2 (0.35) | CHRM2CHRM3CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412798-A2 | Substituted pyridines, their preparation, formulations and use in dementia | MERCK SHARP & DOHME LTD. (GB) | 1991-02-13 | — | — | EP | claimed |
| US-5346906-A | Enhancement of cholinergic transmitters in treatment of neurological and mental disorders such as Alzheimer's | MERCK SHARPE & DOHME LTD. (GB) | 1994-09-13 | — | — | US | disclosed |
| EP-0412798-A2 | Substituted pyridines, their preparation, formulations and use in dementia | MERCK SHARP & DOHME LTD. (GB) | 1991-02-13 | — | — | EP | disclosed |