Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 5/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.68 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.68 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.68 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8775364 | 0.91 | KMT2A (0.61) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9430906 | 0.81 | CHRM1 (1.00) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9458699 | 0.81 | CHRM1 (0.69) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL7755543 | 0.79 | KMT2A (0.69) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL9492300 | 0.79 | KMT2A (0.69) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL8775322 | 0.79 | CHRM1 (0.59) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL8775260 | 0.78 | CHRM1 (0.73) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL8775378 | 0.78 | KMT2A (0.58) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL8775603 | 0.77 | CHRM1 (0.60) | CHRM1CHRM2CHRM4CHRM5CHRM3 | |
| SCHEMBL8777872 | 0.77 | KMT2A (0.65) | CHRM1CHRM2CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5346906-A | Enhancement of cholinergic transmitters in treatment of neurological and mental disorders such as Alzheimer's | MERCK SHARPE & DOHME LTD. (GB) | 1994-09-13 | — | — | US | disclosed |
| EP-0412798-A2 | Substituted pyridines, their preparation, formulations and use in dementia | MERCK SHARP & DOHME LTD. (GB) | 1991-02-13 | — | — | EP | disclosed |