Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 5/20 | 0.43 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | TACR3 | P29371 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 5/20 | 0.35 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9432327 | 0.78 | AKR1B1 (0.52) | AKR1B1KIF11AKR1B10MAPTAKR1A1 | |
| SCHEMBL9432807 | 0.77 | AKR1B1 (0.46) | AKR1B1KIF11AKR1B10MAPTAKR1A1 | |
| SCHEMBL10754485 | 0.75 | AKR1B1 (0.49) | AKR1B1KIF11AKR1B10MAPTAKR1A1 | |
| SCHEMBL9432026 | 0.74 | AKR1B1 (0.51) | AKR1B1KIF11AKR1B10MAPTAKR1A1 | |
| SCHEMBL9433439 | 0.72 | AKR1B1 (0.48) | AKR1B1GRM5 | |
| SCHEMBL9433428 | 0.72 | AKR1B1 (0.48) | AKR1B1GRM5 | |
| SCHEMBL9433435 | 0.72 | AKR1B1 (0.48) | AKR1B1GRM5 | |
| SCHEMBL7177095 | 0.70 | AKR1B1 (0.55) | AKR1B1KIF11AKR1B10MAPTAKR1A1 | |
| SCHEMBL10653318 | 0.69 | AKR1B1 (0.47) | AKR1B1AKR1B10MAPTAKR1A1ALDH1A1 | |
| SCHEMBL10650449 | 0.69 | AKR1B1 (0.47) | AKR1B1AKR1B10MAPTAKR1A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294635-A | Heterocyclic compounds as aldose reductase inhibitors | PFIZER, INC. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0530198-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1991015491-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1991-10-17 | — | — | WO | disclosed |
| US-5039672-A | Administering enzyme inhibitors to control diabetes | PFIZER INC. (US) | 1991-08-13 | — | — | US | disclosed |