Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.41 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 2/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | RARA | P10276 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | RARG | P13631 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9432327 | 0.84 | AKR1B1 (0.52) | AKR1B1SMN1; SMN2AKR1B10MAPTAKR1A1 | |
| SCHEMBL9432026 | 0.80 | AKR1B1 (0.51) | AKR1B1SMN1; SMN2AKR1B10MAPTAKR1A1 | |
| SCHEMBL9432149 | 0.77 | AKR1B1 (0.43) | AKR1B1AKR1B10MAPTAKR1A1ALDH1A1 | |
| SCHEMBL7177095 | 0.75 | AKR1B1 (0.55) | AKR1B1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL9533253 | 0.75 | KMT2A (0.39) | AKR1B1SMN1; SMN2KIF11CTNNB1 | |
| SCHEMBL10574215 | 0.74 | AKR1B1 (0.51) | AKR1B1AKR1B10MAPTAKR1A1ALDH1A1 | |
| SCHEMBL9536563 | 0.74 | AKR1B1 (0.51) | AKR1B1AKR1B10MAPTAKR1A1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10572120 | 0.73 | AKR1B1 (0.50) | AKR1B1AKR1B10MAPTAKR1A1ALDH1A1 | |
| SCHEMBL9432435 | 0.71 | AKR1B1 (0.60) | AKR1B1AKR1B10MAPTAKR1A1KIF11 | |
| SCHEMBL10577363 | 0.70 | AKR1B1 (0.47) | AKR1B1AKR1B10MAPTAKR1A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294635-A | Heterocyclic compounds as aldose reductase inhibitors | PFIZER, INC. (US) | 1994-03-15 | — | — | US | disclosed |
| EP-0530198-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1993-03-10 | — | — | EP | disclosed |
| WO-1991015491-A1 | HETEROCYCLIC COMPOUNDS AS ALDOSE REDUCTASE INHIBITORS | PFIZER INC. (US) | 1991-10-17 | — | — | WO | disclosed |
| US-5039672-A | Administering enzyme inhibitors to control diabetes | PFIZER INC. (US) | 1991-08-13 | — | — | US | disclosed |