Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5162275 | 0.84 | AKR1B1 (0.44) | AKR1B1 | |
| SCHEMBL9432299 | 0.78 | SLC6A3 (0.41) | SLC6A4SLC6A3AKR1B1 | |
| SCHEMBL28108302 | 0.70 | PTGS1 (0.37) | SLC6A4SLC6A3 | |
| SCHEMBL25625143 | 0.70 | KMT2A (0.37) | — | |
| SCHEMBL1569835 | 0.67 | PTGDR2 (0.42) | — | |
| SCHEMBL28108305 | 0.65 | PTGS1 (0.37) | SLC6A4SLC6A3AKR1B1 | |
| SCHEMBL913653 | 0.65 | KDM4E (0.35) | SLC6A4SLC6A3 | |
| SCHEMBL17571869 | 0.64 | SLC6A4 (0.36) | SLC6A4SLC6A3 | |
| SCHEMBL3096933 | 0.64 | SLC6A4 (0.39) | SLC6A4SLC6A3 | |
| SCHEMBL10898016 | 0.64 | HCRTR2 (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5294635-A | Heterocyclic compounds as aldose reductase inhibitors | PFIZER, INC. (US) | 1994-03-15 | — | — | US | disclosed |
| US-5039672-A | Administering enzyme inhibitors to control diabetes | PFIZER INC. (US) | 1991-08-13 | — | — | US | disclosed |