Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.66 |
| ▸ | RHEB | Q15382 | 6/20 | 0.51 |
| ▸ | ULK1 | O75385 | 1/20 | 0.49 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20536478 | 0.88 | RHEB (0.69) | GRIN1RHEBULK1EIF4A3CYP1A2 | |
| SCHEMBL26372677 | 0.86 | ULK1 (0.48) | GRIN1RHEBULK1EIF4A3CYP1A2 | |
| SCHEMBL24020832 | 0.84 | ULK1 (0.53) | GRIN1RHEBULK1CYP1A2NR4A2 | |
| SCHEMBL20535730 | 0.84 | ULK1 (0.47) | GRIN1RHEBULK1CYP1A2NR4A2 | |
| SCHEMBL30310315 | 0.84 | GRIN1 (0.50) | GRIN1RHEBULK1EIF4A3CYP1A2 | |
| SCHEMBL24020651 | 0.84 | GRIN1 (0.50) | GRIN1RHEBULK1EIF4A3CYP1A2 | |
| SCHEMBL7650520 | 0.84 | ULK1 (0.47) | GRIN1RHEBULK1CYP1A2NR4A2 | |
| SCHEMBL30310577 | 0.84 | ULK1 (0.53) | GRIN1RHEBULK1CYP1A2NR4A2 | |
| SCHEMBL20536009 | 0.84 | ULK1 (0.47) | GRIN1RHEBULK1EIF4A3CYP1A2 | |
| SCHEMBL24020677 | 0.84 | ULK1 (0.47) | GRIN1RHEBULK1EIF4A3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5284862-A | Neurodegenerative disorders including cerebrovascular disorders; antagonists for excitatory amino acid receptors | WARNER-LAMBERT COMPANY (US) | 1994-02-08 | — | — | US | disclosed |
| WO-1992016205-A2 | NOVEL DERIVATIVES OF 2-CARBOXYNDOLES HAVING PHARMACEUTICAL ACTIVITY | WARNER-LAMBERT COMPANY (US) | 1992-10-01 | — | — | WO | disclosed |