Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 13/20 | 0.75 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.59 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.57 |
| ▸ | CLK1 | P49759 | 1/20 | 0.57 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.57 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326985 | 0.89 | CSNK2A2 (0.62) | HPGDPTPN1CSNK2A2CLK1CSNK2B | |
| SCHEMBL9311896 | 0.87 | HPGD (0.58) | HPGDPTPN1CSNK2A2CLK1CSNK2B | |
| SCHEMBL1300345 | 0.86 | HPGD (1.00) | HPGDPTPN1MAOAMAOBPOLB | |
| SCHEMBL6866778 | 0.86 | HPGD (1.00) | HPGDPTPN1MAOAMAOBPOLB | |
| SCHEMBL1300347 | 0.86 | HPGD (1.00) | HPGDPTPN1MAOAMAOBPOLB | |
| SCHEMBL9124681 | 0.82 | HPGD (0.53) | HPGDPTPN1CSNK2A2CLK1CSNK2B | |
| SCHEMBL9803959 | 0.81 | CSNK2A2 (0.62) | HPGDCSNK2A2CLK1CSNK2BCSNK2A1 | |
| SCHEMBL9430658 | 0.81 | HPGD (0.51) | HPGDPTPN1CSNK2A2CLK1CSNK2B | |
| SCHEMBL9327176 | 0.80 | PPARG (0.64) | HPGDPTPN1CSNK2A2CLK1CSNK2B | |
| SCHEMBL6866151 | 0.80 | HPGD (1.00) | HPGDPTPN1MAOAMAOBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5326770-A | Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazolidinediones useful in treating memory disorders of mammals | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-07-05 | — | — | US | disclosed |