SCHEMBL943657

SCHEMBL943657

O=C(O)CN1C[C@@H](O)[C@H](O)[C@H]1CO

nearest known ligand 0.58

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
AGL P35573 3/20 0.58
GAA P10253 9/20 0.52
MGAM O43451 5/20 0.52
SI P14410 3/20 0.52
GBA1 P04062 2/20 0.52
TDP1 Q9NUW8 1/20 0.52
LCT P09848 1/20 0.52
GBA2 Q9HCG7 6/20 0.46
UGCG Q16739 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2433211 1.00 AGL (0.58) AGLGAAMGAMSIGBA1
SCHEMBL2437299 0.94 GAA (0.59) AGLGAAMGAMSIGBA1
SCHEMBL942535 0.94 GAA (0.59) AGLGAAMGAMSIGBA1
SCHEMBL12909423 0.94 GAA (0.59) AGLGAAMGAMSIGBA1
SCHEMBL22693211 0.79 AGL (0.61) AGLGAAMGAMSIGBA1
SCHEMBL22693281 0.78 AGL (0.59) AGLGAAGBA1GBA2UGCG
SCHEMBL2124252 0.77 AGL (0.69) AGLGAAMGAMSIGBA1
SCHEMBL9485658 0.77 AGL (0.69) AGLGAAMGAMSIGBA1
SCHEMBL2124249 0.77 AGL (0.69) AGLGAAMGAMSIGBA1
SCHEMBL17795750 0.77 GAA (0.66) AGLGAAMGAMSIGBA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1163217-B1 NEW SALT OF (2R,3R,4R)-3,4-DIHYDROXY-2-HYDROXYMETHYLPYRROLIDINE NOVO NORDISK AS (DK) 2005-09-21 EP claimed
US-11484561-B2 Morus extracts rich in N-acids of imino sugars and or pipecolic acids PHYNOVA LIMITED 2022-11-01 US disclosed
US-10842784-B2 Treatment of energy utilization disease VIDA PHARMA LIMITED (GB) 2020-11-24 US disclosed
US-10842784-B2 Treatment of energy utilization disease VIDA PHARMA LIMITED (GB) 2020-11-24 US disclosed
EP-2776050-B1 MORUS EXTRACTS RICH IN N-ACIDS OF IMINO SUGARS AND OR PIPECOLIC ACIDS PHYNOVA LTD (GB) 2020-06-24 EP disclosed
EP-2257286-B1 TREATMENT OF ENERGY UTILIZATION DISEASE SUMMIT CORP PLC (GB) 2016-12-28 EP disclosed
US-20160151341-A1 TREATMENT OF ENERGY UTILIZATION DISEASE SUMMIT CORPORATION PLC (GB) 2016-06-02 US disclosed
US-20160151341-A1 TREATMENT OF ENERGY UTILIZATION DISEASE SUMMIT CORPORATION PLC (GB) 2016-06-02 US disclosed
US-20160151341-A1 TREATMENT OF ENERGY UTILIZATION DISEASE SUMMIT CORPORATION PLC (GB) 2016-06-02 US disclosed
US-20140328950-A1 MORUS EXTRACTS RICH IN N-ACIDS OF IMINO SUGARS AND OR PIPECOLIC ACIDS PHYNOVA LIMITED (GB) 2014-11-06 US disclosed
US-20140328950-A1 MORUS EXTRACTS RICH IN N-ACIDS OF IMINO SUGARS AND OR PIPECOLIC ACIDS PHYNOVA LIMITED (GB) 2014-11-06 US disclosed
WO-2013068715-A1 MORUS EXTRACTS RICH IN N-ACIDS OF IMINO SUGARS AND OR PIPECOLIC ACIDS PHYNOVA LIMITED (GB) 2013-05-16 WO disclosed
US-20110015226-A1 Treatment of Energy Utilization Disease SUMMIT CORPORATION PLC (GB) 2011-01-20 US disclosed
US-20110015226-A1 Treatment of Energy Utilization Disease SUMMIT CORPORATION PLC (GB) 2011-01-20 US disclosed
US-20110015226-A1 Treatment of Energy Utilization Disease SUMMIT CORPORATION PLC (GB) 2011-01-20 US disclosed
EP-1163217-B1 NEW SALT OF (2R,3R,4R)-3,4-DIHYDROXY-2-HYDROXYMETHYLPYRROLIDINE NOVO NORDISK AS (DK) 2005-09-21 EP disclosed
EP-1163217-A1 NEW SALT OF (2R,3R,4R)-3,4-DIHYDROXY-2-HYDROXYMETHYLPYRROLIDINE NOVO NORDISK A/S (DK) 2001-12-19 EP disclosed
US-6316489-B1 FOR THERAPY AND PROPHYLAXIS OF DIABETES, OBESITY OR APPETITE REGULATION NOVO NORDISK A/S (DK) 2001-11-13 US disclosed
WO-2000055131-A1 NEW SALT OF (2R,3R,4R)-3,4-DIHYDROXY-2-HYDROXYMETHYLPYRROLIDINE NOVO NORDISK A/S (DK) 2000-09-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10842784-B2 Treatment of energy utilization disease IRS1, SLC2A1, INSR AGL 101/4885GAA 268/4885MGAM 97/4885
US-20110015226-A1 Treatment of Energy Utilization Disease IRS1, SLC2A1, INSR AGL 101/4885GAA 268/4885MGAM 97/4885
US-11484561-B2 Morus extracts rich in N-acids of imino sugars and or pipecolic acids GANC, NUDC, MGAM AGL 1171/4885GAA 106/4885MGAM 3/4885
US-20160151341-A1 TREATMENT OF ENERGY UTILIZATION DISEASE IRS1, SLC2A1, INSR AGL 101/4885GAA 268/4885MGAM 97/4885
US-20140328950-A1 MORUS EXTRACTS RICH IN N-ACIDS OF IMINO SUGARS AND OR PIPECOLIC ACIDS GANC, NUDC, MGAM AGL 1171/4885GAA 106/4885MGAM 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.