Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.58 |
| ▸ | PGC | P20142 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9438037 | 0.91 | REN (0.60) | REN | |
| SCHEMBL9437961 | 0.91 | REN (0.64) | REN | |
| SCHEMBL9438031 | 0.90 | REN (0.68) | REN | |
| SCHEMBL9438007 | 0.90 | REN (0.58) | RENPGC | |
| SCHEMBL9438193 | 0.89 | REN (0.62) | RENPGC | |
| SCHEMBL9438090 | 0.89 | REN (0.59) | RENPGC | |
| SCHEMBL9438113 | 0.89 | REN (0.57) | RENPGC | |
| SCHEMBL9438136 | 0.88 | REN (0.61) | RENPGC | |
| SCHEMBL9438075 | 0.88 | REN (0.58) | RENPGC | |
| SCHEMBL7381075 | 0.88 | REN (0.58) | RENPGC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5328916-A | Renin inhibitors, hypotensive agents | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1994-07-12 | — | — | US | disclosed |
| EP-0456039-A2 | Renin inhibiting amino acid derivatives | MERCK PATENT GmbH (DE) | 1991-11-13 | — | — | EP | disclosed |