SCHEMBL9438422

SCHEMBL9438422

CCc1cccc(N(C(=Nc2ccccc2C(C)C)NC(C)C)C(C)C)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 18/20 0.59
TP53 P04637 1/20 0.39
CYP2D6 P10635 1/20 0.39
TSHR P16473 1/20 0.39
THPO P40225 1/20 0.39
MTOR P42345 1/20 0.39
MEN1 O00255 1/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39
PMP22 Q01453 1/20 0.39
KMT2A Q03164 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
NOS3 P29474 2/20 0.38
NOS1 P29475 2/20 0.38
NOS2 P35228 2/20 0.38
GRIN2D O15399 1/20 0.36
GRIN3B O60391 1/20 0.36
GRIN1 Q05586 1/20 0.36
GRIN2A Q12879 1/20 0.36
GRIN2B Q13224 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9438468 0.87 SIGMAR1 (0.56) SIGMAR1TP53CYP2D6TSHRTHPO
SCHEMBL6719325 0.83 SIGMAR1 (0.77) SIGMAR1TP53CYP2D6TSHRTHPO
SCHEMBL8401661 0.82 SIGMAR1 (0.51) SIGMAR1GRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL8334405 0.81 SIGMAR1 (0.39) SIGMAR1TP53CYP2D6TSHRTHPO
SCHEMBL8329442 0.81 SIGMAR1 (0.39) SIGMAR1TP53CYP2D6TSHRTHPO
SCHEMBL9438424 0.76 SIGMAR1 (0.46) SIGMAR1MEN1MAPTKMT2AGRIN2D
SCHEMBL6728156 0.74 SIGMAR1 (1.00) SIGMAR1TP53CYP2D6TSHRTHPO
SCHEMBL6716625 0.74 SIGMAR1 (0.77) SIGMAR1TP53CYP2D6TSHRTHPO
SCHEMBL6719320 0.71 SIGMAR1 (0.46) SIGMAR1MEN1MAPTKMT2A
SCHEMBL6721243 0.71 SIGMAR1 (0.48) SIGMAR1TP53CYP2D6TSHRTHPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0517852-A4 1994-03-02 EP disclosed
EP-0517852-A1 TRI- AND TETRA-SUBSTITUTED GUANIDINES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS STATE OF OREGON, acting through OREGON STATE BOARD OF HIGHER EDUCATION, acting for OREGON HEALTH SC. UNIV. AND UNIV. OF OREGON (US) 1992-12-16 EP disclosed
WO-1991012797-A1 TRI- AND TETRA-SUBSTITUTED GUANIDINES AND THEIR USE AS EXCITATORY AMINO ACID ANTAGONISTS STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALF SCIENCES UNIVERSITY (US) 1991-09-05 WO disclosed