Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 3/20 | 0.37 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PER2 | O15055 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7295178 | 1.00 | PIK3CD (0.39) | PIK3CDTSHRGAAKDM4EALDH1A1 | |
| SCHEMBL7304819 | 0.79 | MEN1 (0.37) | SMN1; SMN2KMT2ARENHTTPSEN1 | |
| SCHEMBL7294726 | 0.78 | PIK3CD (0.44) | PIK3CDTSHRGAAKMT2AREN | |
| SCHEMBL7295043 | 0.78 | GAA (0.37) | PIK3CDTSHRGAAKDM4EALDH1A1 | |
| SCHEMBL9439337 | 0.78 | GAA (0.37) | PIK3CDTSHRGAAKDM4EALDH1A1 | |
| SCHEMBL969137 | 0.74 | GRN (0.40) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL967760 | 0.74 | GRN (0.40) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3347419 | 0.74 | PSEN1 (0.39) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL970762 | 0.74 | GRN (0.40) | RENPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL968972 | 0.73 | CYP2D6 (0.42) | ALDH1A1RENPSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5278148-A | Hypotensive agents | HOFFMANN-LA ROCHE INC. (US) | 1994-01-11 | — | — | US | disclosed |