Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 2/20 | 0.61 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.61 |
| ▸ | CTSG | P08311 | 2/20 | 0.59 |
| ▸ | CMA1 | P23946 | 2/20 | 0.59 |
| ▸ | ACE | P12821 | 4/20 | 0.55 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.55 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | CDC25B | P30305 | 1/20 | 0.53 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.51 |
| ▸ | MME | P08473 | 3/20 | 0.51 |
| ▸ | CPA1 | P15085 | 1/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.51 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9440326 | 1.00 | ITGB3 (0.61) | ITGB3ITGA2BCTSGCMA1ACE | |
| SCHEMBL4153095 | 0.91 | ITGB3 (0.65) | ITGB3ITGA2BCTSGCMA1ACE | |
| SCHEMBL4153101 | 0.91 | ITGB3 (0.65) | ITGB3ITGA2BCTSGCMA1ACE | |
| SCHEMBL5458748 | 0.91 | ITGB3 (0.65) | ITGB3ITGA2BCTSGCMA1ACE | |
| SCHEMBL4147417 | 0.87 | ITGB3 (0.62) | ITGB3ITGA2BACEPIN1PTPN2 | |
| SCHEMBL4147927 | 0.87 | ITGB3 (0.62) | ITGB3ITGA2BACEPIN1PTPN2 | |
| SCHEMBL4147924 | 0.87 | ITGB3 (0.62) | ITGB3ITGA2BACEPIN1PTPN2 | |
| SCHEMBL4147413 | 0.87 | ITGB3 (0.62) | ITGB3ITGA2BACEPIN1PTPN2 | |
| SCHEMBL9440106 | 0.87 | HDAC1 (0.59) | CTSGCMA1 | |
| SCHEMBL9440111 | 0.87 | HDAC1 (0.59) | CTSGCMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526488-B1 | BENZYLPHOSPHONIC ACID TYROSINE KINASE INHIBITORS | PFIZER (US) | 1994-11-30 | — | — | EP | disclosed |
| US-5326905-A | Benzylphosphonic acid tyrosine kinase inhibitors | PFIZER INC. (US) | 1994-07-05 | — | — | US | disclosed |
| EP-0526488-A1 | BENZYLPHOSPHONIC ACID TYROSINE KINASE INHIBITORS. | PFIZER (US) | 1993-02-10 | — | — | EP | disclosed |
| WO-1991015495-A1 | BENZYLPHOSPHONIC ACID TYROSINE KINASE INHIBITORS | PFIZER INC. (US) | 1991-10-17 | — | — | WO | disclosed |