Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11120507 | 0.85 | PTGS2 (0.38) | PTGS2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL9745891 | 0.85 | PTGS2 (0.41) | PTGS2PTGS1 | |
| SCHEMBL11121594 | 0.84 | PTGS2 (0.39) | PTGS2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL11123145 | 0.84 | PTGS2 (0.39) | PTGS2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL11120600 | 0.84 | PTGS2 (0.42) | PTGS2PTGS1 | |
| SCHEMBL9441765 | 0.81 | FFAR4 (0.44) | — | |
| SCHEMBL11131311 | 0.80 | PTGS2 (0.41) | PTGS2PTGS1DAPK3NTRK1PIM1 | |
| SCHEMBL9602188 | 0.80 | PTGS2 (0.43) | PTGS2PTGS1 | |
| SCHEMBL5171324 | 0.80 | PTGS2 (0.44) | PTGS2PTGS1 | |
| SCHEMBL5170477 | 0.80 | PTGS2 (0.41) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5276021-A | Anticholesterol or antilipemic agents | E. R. SQUIBB & SONS, INC. (US) | 1994-01-04 | — | — | US | disclosed |
| US-5091378-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-02-25 | — | — | US | disclosed |
| US-5053525-A | Hmg-coa reductase inhibitors | MERCK & CO., INC. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0142146-B1 | OXO-ANALOGS OF MEVINOLIN-LIKE ANTIHYPERCHOLESTEROLEMIC AGENTS | MERCK & CO. INC. (US) | 1988-08-31 | — | — | EP | disclosed |
| EP-0142146-A2 | Oxo-analogs of mevinolin-like antihypercholesterolemic agents | MERCK & CO. INC. (US) | 1985-05-22 | — | — | EP | disclosed |