Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 4/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9444391 | 0.86 | KCNH2 (0.49) | CYP2D6KCNH2CYP2C19CYP3A4KDM4E | |
| SCHEMBL9444381 | 0.77 | KCNH2 (0.56) | CYP2D6KCNH2CYP2C19CYP3A4KDM4E | |
| SCHEMBL9444369 | 0.77 | KCNH2 (0.57) | CYP2D6KCNH2CYP2C19CYP3A4KDM4E | |
| Hydrochloric Acid SCHEMBL9444437 | 0.76 | POLB (0.58) | CYP2D6KCNH2CYP2C19CYP3A4KDM4E | |
| SCHEMBL16447297 | 0.75 | CYP2C19 (0.54) | CYP2D6KCNH2CYP2C19CYP3A4KDM4E | |
| SCHEMBL9444333 | 0.75 | KCNH2 (0.66) | CYP2D6KCNH2CYP2C19CYP3A4KDM4E | |
| SCHEMBL9444327 | 0.75 | KCNH2 (0.53) | CYP2D6KCNH2CYP2C19CYP3A4KDM4E | |
| Hydrochloric Acid SCHEMBL9444310 | 0.74 | KCNH2 (0.67) | CYP2D6KCNH2CYP2C19CYP3A4KDM4E | |
| SCHEMBL9444444 | 0.74 | KCNH2 (0.59) | CYP2D6KCNH2CYP2C19CYP3A4KDM4E | |
| SCHEMBL9444462 | 0.74 | KCNH2 (0.48) | CYP2D6KCNH2CYP2C19CYP3A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0235752-B1 | Piperidine derivative, pharmaceutical composition containing the same and use | EISAI CO LTD (JP) | 1993-11-18 | — | — | EP | disclosed |
| US-5179095-A | Antiarrhythmia agents | EISAI CO., LTD. (JP) | 1993-01-12 | — | — | US | disclosed |
| US-5118689-A | Antiarrhythmia agents | EISAI CO., LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4996215-A | Antiarrythmia agents | EISAI CO., LTD. (JP) | 1991-02-26 | — | — | US | disclosed |
| US-4876262-A | ANTIARRHYTHMIA AGENTS | EISAI CO., LTD. (JP) | 1989-10-24 | — | — | US | disclosed |
| EP-0235752-A2 | Piperidine derivative, pharmaceutical composition containing the same and use | Eisai Co., Ltd. (JP) | 1987-09-09 | — | — | EP | disclosed |