Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 5/20 | 0.60 |
| ▸ | RARG | P13631 | 5/20 | 0.60 |
| ▸ | RARB | P10826 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 7/20 | 0.59 |
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8461601 | 0.81 | CYP26A1 (0.82) | RARARARGRARBMEN1KMT2A | |
| SCHEMBL8461304 | 0.78 | RARA (0.78) | RARARARGRARBMEN1KMT2A | |
| SCHEMBL446436 | 0.78 | MAPT (0.55) | RARARARGRARBMEN1KMT2A | |
| SCHEMBL7152370 | 0.78 | RARB (0.91) | RARARARGRARBMEN1KMT2A | |
| SCHEMBL7155758 | 0.77 | RARA (0.80) | RARARARGRARBMEN1KMT2A | |
| SCHEMBL15655870 | 0.76 | RARG (0.59) | RARARARGRARBMEN1KMT2A | |
| SCHEMBL3935697 | 0.75 | RARB (0.64) | RARARARGRARBMEN1KMT2A | |
| SCHEMBL32685293 | 0.75 | RARB (0.68) | RARARARGRARBMEN1KMT2A | |
| SCHEMBL12715266 | 0.75 | CYP26A1 (0.67) | RARARARGRARBMEN1KMT2A | |
| SCHEMBL30590581 | 0.75 | RARA (1.00) | RARARARGRARBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5216153-A | Therapy and prophylaxis for skin, autoimmune and rheumatic diseases | HOFFMANN-LA ROCHE INC. (US) | 1993-06-01 | — | — | US | claimed |