Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.41 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9447468 | 0.89 | KCNH2 (0.52) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9678401 | 0.86 | KCNH2 (0.52) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9676515 | 0.85 | KCNH2 (0.54) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9678090 | 0.84 | KCNH2 (0.52) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9447556 | 0.82 | KCNH2 (0.64) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9677412 | 0.81 | KCNH2 (0.55) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9447432 | 0.78 | KCNH2 (0.53) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E | |
| SCHEMBL9625720 | 0.74 | CACNA1F (0.64) | KCNH2KDM4ECACNA1FCHRM2ADRA2B | |
| Hydrochloric Acid SCHEMBL9625546 | 0.73 | CACNA1F (0.63) | KCNH2KDM4ECACNA1FCHRM2ADRA2B | |
| SCHEMBL9692733 | 0.72 | KCNH2 (0.50) | KCNH2CYP3A4CYP2D6CYP2C19KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246946-A | Antiarrhythmia agents and cardiovascular disorders | EISAI CO., LTD. (JP) | 1993-09-21 | — | — | US | disclosed |
| EP-0304888-B1 | SULFONAMIDOLPHENYL DERIVATES AND THERAPEUTIC AND PREVENTIVE AGENTS FOR ARRYTHMIA CONTAINING SAME | Eisai Co., Ltd. (JP) | 1992-11-11 | — | — | EP | disclosed |
| US-5162347-A | Piperidine derivatives and therapeutic and preventive agents for arrhythmia containing same | EISAI CO., LTD. (JP) | 1992-11-10 | — | — | US | disclosed |
| US-5082850-A | PIPERIDINE DERIVATIVES AND THERAPEUTIC AND PREVENTIVE AGENTS FOR ARRHYTHMIA CONTAINING SAME | EISAI CO., LTD. (JP) | 1992-01-21 | — | — | US | disclosed |
| US-4977165-A | Piperidine derivative and therapeutic and preventive agents for arrhythmia containing same | EISAI CO., LTD. (JP) | 1990-12-11 | — | — | US | disclosed |
| EP-0304888-A1 | Sulfonamidolphenyl derivates and therapeutic and preventive agents for arrythmia containing same | Eisai Co., Ltd. (JP) | 1989-03-01 | — | — | EP | disclosed |