Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EED | O75530 | 1/20 | 0.45 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9447871 | 1.00 | EED (0.45) | EEDGID4HCRTR1HCRTR2CHRM4 | |
| Hydrochloric Acid SCHEMBL9448271 | 0.99 | EED (0.44) | EEDGID4HCRTR1HCRTR2CHRM4 | |
| Hydrochloric Acid SCHEMBL9448278 | 0.99 | EED (0.44) | EEDGID4HCRTR1HCRTR2CHRM4 | |
| SCHEMBL9447972 | 0.92 | EED (0.46) | EEDCHRM4DRD2HTR7SLC6A4 | |
| SCHEMBL9448043 | 0.88 | NPY5R (0.48) | HTR1ASIGMAR1 | |
| SCHEMBL9448048 | 0.88 | NPY5R (0.48) | HTR1ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL9448267 | 0.87 | NPY5R (0.48) | HTR1ASIGMAR1 | |
| SCHEMBL9448224 | 0.85 | PRCP (0.36) | OPRM1SIGMAR1 | |
| SCHEMBL9447997 | 0.85 | PRCP (0.36) | OPRM1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9448301 | 0.84 | OPRM1 (0.36) | OPRM1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5248677-A | Nervous system disorders or antidepressants | ABBOTT LABORATORIES (US) | 1993-09-28 | — | — | US | disclosed |
| US-5180733-A | Antidepressants or nervous systen disorders | ABBOTT LABORATORIES (US) | 1993-01-19 | — | — | US | disclosed |
| EP-0461353-A1 | Biogenic amine uptake inhibitors | ABBOTT LABORATORIES (US) | 1991-12-18 | — | — | EP | disclosed |