Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 3/20 | 0.35 |
| ▸ | FNTB | P49356 | 3/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.32 |
| ▸ | STS | P08842 | 4/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9448190 | 0.88 | CYP19A1 (0.43) | TRPV1SLC6A9NPY5R | |
| SCHEMBL9448017 | 0.86 | TRPV1 (0.35) | TRPV1SRD5A1STSKDM1AACHE | |
| SCHEMBL9448214 | 0.82 | NPY5R (0.31) | NPY5R | |
| SCHEMBL9448187 | 0.80 | CYP19A1 (0.43) | ACHE | |
| SCHEMBL9448101 | 0.80 | GRM7 (0.37) | — | |
| SCHEMBL9448202 | 0.78 | SRD5A1 (0.35) | FNTAFNTBTRPV1MMP2SRD5A1 | |
| SCHEMBL9448449 | 0.77 | TRPV1 (0.38) | TRPV1SRD5A1 | |
| SCHEMBL9448284 | 0.76 | CYP19A1 (0.40) | TRPV1SLC6A9NPY5R | |
| SCHEMBL9448316 | 0.74 | STS (0.39) | FNTAFNTBTRPV1SRD5A1STS | |
| SCHEMBL9448311 | 0.74 | STS (0.39) | FNTAFNTBTRPV1SRD5A1STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5248677-A | Nervous system disorders or antidepressants | ABBOTT LABORATORIES (US) | 1993-09-28 | — | — | US | disclosed |
| US-5180733-A | Antidepressants or nervous systen disorders | ABBOTT LABORATORIES (US) | 1993-01-19 | — | — | US | disclosed |
| EP-0461353-A1 | Biogenic amine uptake inhibitors | ABBOTT LABORATORIES (US) | 1991-12-18 | — | — | EP | disclosed |