Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 20/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 20/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 18/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9448446 | 0.80 | SIRT2 (0.47) | SIRT2SIRT3SIRT1 | |
| SCHEMBL9448549 | 0.79 | SIRT2 (0.48) | SIRT2SIRT3SIRT1 | |
| SCHEMBL9448533 | 0.79 | SIRT2 (0.48) | SIRT2SIRT3SIRT1 | |
| SCHEMBL9448322 | 0.79 | SIRT2 (0.48) | SIRT2SIRT3SIRT1 | |
| SCHEMBL9448330 | 0.78 | SIRT2 (0.46) | SIRT2SIRT3SIRT1 | |
| SCHEMBL9448534 | 0.78 | PARP10 (0.56) | SIRT2SIRT3SIRT1 | |
| SCHEMBL9448471 | 0.77 | SIRT2 (0.45) | SIRT2SIRT3SIRT1 | |
| SCHEMBL9448404 | 0.77 | SIRT2 (0.49) | SIRT2SIRT3SIRT1 | |
| SCHEMBL9448346 | 0.76 | SIRT2 (0.52) | SIRT2SIRT3SIRT1 | |
| SCHEMBL9448400 | 0.75 | SIRT2 (0.50) | SIRT2SIRT3SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5215738-A | Used for destroying hypoxic tumor cells | SRI INTERNATIONAL (US) | 1993-06-01 | — | — | US | disclosed |
| WO-1986006628-A1 | BENZAMIDE AND NICOTINAMIDE RADIOSENSITIZERS | SRI INTERNATIONAL (US) | 1986-11-20 | — | — | WO | disclosed |